American Horror Story star Rose Higgins has died aged 43.
The mother of two had undergone kidney stone surgery but subsequently developed an infection, reported TMZ.
She died in a Denver area hospital early on Saturday morning.
Rose was born with sacral agenesis, a spinal deformation that limits use of the legs.
Mourned: Actress Rose Siggns has died following kidney stone surgery aged 43
According to TMZ she had suffered from kidney and pancreas issues since birth.
A GoFundMe page set up to cover the cost of Rose's treatment, updated fans on the sad news.
'I'm sad to report that Rose has passed away this morning around 7.30am,' her management team wrote in a statement.
'All funds raised will now be directed to final expenses and the continuing support of her children.'
Rose is survived by her husband, David, and children, Luke, 16, and Shelby, nine, who she called her 'miracle' babies.
Fame: Rose played Legless Suzi the fourth season of American Horror Story, which aired from 2014 to 2015
The actress did not let her lifelong illness stop her achieving her goals - whether that be starring on the small screen, or starting a family.
'Getting around is slower these days,' she told the Huffington Post back in 2012.
'A lot of people with disabilities feel that life owes them something, and I was raised in a way that no one owes you a dime. The world doesn’t owe you anything.
'My personal opinion is, get up and go for it.'
Family: Rose with her husband David and children, Luke and Shelby back in 2006
Rose played Legless Suzi in the fourth season of American Horror Story, which aired from 2014 to 2015.
Earlier this year her co-star Ben Woolf, who played Meep, died in a Los Angeles hospital aged 34.
The 4ft4 actor suffered a stroke after he was hit in the head by a car's wing mirror while crossing the street in Hollywood.
Red carpet: Rose used a skateboard to get around; she is seen at the Chinese Theatre in Hollywood last year
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